BY: News Peddlers
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| Couples in Bed |
According to a Weill Cornell Medicine report, a contraceptive pill is being developed to stop sperm by preventing pregnancies in preclinical models.
The drug being tested would show that "on-demand male contraception" is possible. Weill Cornell Medicine pharmacology professors Jochen Buck and Lonny Levin stated in a February 14 press release.
Condoms, according to Messrs Buck and Levin, have been available to men for approximately 2,000 years.
"Research on male oral contraceptives has stalled, partly because potential contraceptives for men must clear a much higher bar for safety and side effects," Mr Levin wrote in the study, adding, "Because men do not bear the risks associated with carrying a contraceptive pill."
Ms Balbach discovered that mice given a drug that inhibits sAC produce sperm that cannot move forward. According to her, sAC inhibition could be a safe contraceptive option for infertile men who lack the sAC gene.
According to the new "Nature Communications" study, a single dose of a sAC inhibitor called TDI-11861 immobilises mice sperm for up to two and a half hours, with the effects persisting in the female reproductive tract after mating.
"After three hours, some sperm begin regaining motility; by 24 hours, nearly all sperm have recovered normal movement. Our inhibitor works in 30 minutes to an hour, whereas every other experimental hormonal or nonhormonal male contraceptive takes weeks to reduce sperm count or render sperm infertile," Ms Balbach explained.
She added that reversing the effects of other hormonal and nonhormonal male contraceptives in development takes weeks.
She also observed that because sAC inhibitors wear off in a matter of hours, "men would only take it when and as often as needed."
The team's next step is to replicate their experiments in a different preclinical model.
These studies would lay the groundwork for human clinical trials testing the effect of sAC inhibition on sperm motility in healthy males.